有关吸烟对于药物在体内转运的影响,主要是由于吸烟促使药物代谢活性的提高己引起人们的注意。特别是对药物血清蛋白的结合率的影响作了研究。报告认为吸烟者对利多卡因的血清蛋白结合率比不吸烟者高,但不使苯妥英的结合率有所变化。其原因推测是由于血中的α_1-酸性糖蛋白(α_1-AGP)浓度增加。但是α_1-AGP的血中浓度不仅受吸烟习惯,而且与性别、年龄、使用口服避孕药 The impact of smoking on the drug transport in the body, mainly due to smoking to promote the improvement of drug metabolism activity has drawn people’s attention. In particular, the influence of the binding rate of the drug serum protein was investigated. Reported that smokers with lidocaine serum protein binding rate higher than non-smokers, but does not change the binding rate of phenytoin. The reason for this is presumed to be due to an increase in the concentration of α 1-acid glycoprotein (α 1 -AGP) in the blood. However, the blood concentration of α_1-AGP is not only affected by smoking habits, but also by gender, age, use of oral contraceptives