奥美拉唑的作用是通过抑制壁细胞质子泵H~+、K~+-ATP酶而降低胃酸。已有两份奥美拉唑引起男子女性型乳房的单一病例报告。本文作者增加了以后的病例,同时也记录与奥美拉唑相关的阳萎病例。所有病例已报告于世界卫生组织国际药物监测纲要。包括15例阳萎和15例男子女性型乳房或乳房增大患者。所有阳萎患者为男性,平均年龄52.6岁。他们每天口服奥美拉唑20～40mg,到发生阳萎的时间为平均4天。所治疗的疾病 The role of omeprazole is to reduce gastric acid by inhibiting H ~ +, K ~ + -ATPase in parietal proton pump. Two single-case reports of omeprazole in females have been reported. The authors added later cases, but also documented cases of impotence associated with omeprazole. All cases have been reported in the WHO International Drug Monitoring Program. Including 15 cases of impotence and 15 cases of male or female breast enlargement of patients. All impotence patients were male, with an average age of 52.6 years. They daily omeprazole 20 ~ 40mg, to impotence time for an average of 4 days. The disease to be treated