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目的:探讨原发性肝癌(PLC)与乙肝标志物之间的关系及甲胎蛋白(AFP)的临床诊断意义。方法:选择236例确诊患者,检测乙肝标志物及AFP,对乙肝标志物的组成模式及AFP数值进行统计分析。结果:236例PLC患者中,乙型肝炎病毒(HBV)感染占93.64%,其中乙肝表面抗原阳性率为90.68%,乙肝表面抗原(HBsAg)、乙肝e抗体(HBeAb)、乙肝核心抗体(HBcAb)阳性为最常见组成模式,阳性率为63.98%。AFP阳性率为48.73%。结论:PLC与HBV感染密切相关,中老年男性HBsAg、HBeAb、HBcAb阳性者为高危人群。AFP对PLC的早期诊断价值有所局限,对于轻度升高者应加强重视,推荐联合检测提高确诊率,以利于PLC的早期诊断与治疗。
Objective: To investigate the relationship between primary hepatocellular carcinoma (PLC) and hepatitis B (HBV) markers and the clinical diagnostic value of AFP. Methods: A total of 236 confirmed patients were selected for detection of hepatitis B and AFP. Statistical analysis was performed on the pattern of hepatitis B markers and AFP values. Results: Of the 236 patients with PLC, the infection rate of hepatitis B virus was 93.64%, the positive rate of HBsAg was 90.68%, HBsAg, HBeAb, HBcAb, Positive for the most common pattern, the positive rate was 63.98%. AFP positive rate was 48.73%. Conclusion: PLC is closely related to HBV infection. The HBsAg, HBeAb and HBcAb positive in middle-aged and elderly men are at high risk. AFP PLC has limited the value of the early diagnosis, for those with mild increase should pay more attention to recommend a joint test to improve the diagnosis rate in order to facilitate the early diagnosis and treatment of PLC.