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目的探讨血清超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平对慢性脑供血不足(CCCI)患者颈动脉内膜中层厚度(CIMT)的评估价值,为预防心脑血管疾病的发生提供依据。方法选取2012年12月至2013年12月期间我院收治的100例CCCI患者(病例组)和30例同期健康查体者(对照组)。应用彩色多普勒超声检测两组CIMT,并以CIMT≥0.9 mm作为颈动脉内膜增厚指标。根据CIMT将病例组分为增厚组(42例)和非增厚组(58例)。分析3组血清hs-CRP、IL-6、TNF-α水平及血清hs-CRP、IL-6、TNF-α水平与CCCI患者CIMT的关系,并采用工作特征曲线(ROC)分析血清hs-CRP、IL-6、TNF-α水平对CCCI患者颈动脉内膜增厚的预测价值。结果增厚组血清hs-CRP、IL-6、TNF-α水平和CIMT分别为(1.42±1.55)mg/L、(122.06±28.42)μg/L、(26.48±3.09)pg/ml和(1.09±0.28)mm,高于非增厚组[分别为(0.98±0.82)mg/L、(106.54±21.69)μg/L、(18.58±3.15)pg/ml和(0.81±0.08)mm]和对照组[分别为(0.62±0.54)mg/L、(78.66±15.87)μg/L、(12.96±2.85)pg/ml和(0.61±0.15)mm],非增厚组血清hs-CRP、IL-6、TNF-α水平和CIMT明显高于对照组,差异均有统计学意义(P<0.05)。Pearson相关性分析结果显示,血清hs-CRP、IL-6、TNF-α水平与CCCI患者CIMT均呈正相关(P<0.05)。ROC曲线下面积为0.764,血清hs-CRP、IL-6、TNF-α水平可在一定程度上预测CCCI患者颈动脉内膜增厚的发生。结论血清hs-CRP、IL-6、TNF-α水平联合检测可用于CCCI患者CIMT增厚的预测。
Objective To investigate the effects of serum hs-CRP, IL-6 and TNF-α on carotid intima-media thickness in patients with chronic cerebral hypoperfusion Thickness (CIMT) assessment value for the prevention of cardiovascular disease provide the basis for the occurrence. Methods From December 2012 to December 2013, 100 patients with CCCI (case group) and 30 healthy people (control group) were enrolled in our hospital. Two sets of CIMT were detected by color Doppler ultrasound, and CIMT≥0.9 mm was used as the intima-media thickness index of carotid artery. The cases were divided into thickened group (42 cases) and non-thickened group (58 cases) according to CIMT. The levels of serum hs-CRP, IL-6, TNF-α and the serum levels of hs-CRP, IL-6 and TNF-α in patients with CCCI were analyzed. The serum hs-CRP , IL-6, TNF-α levels in predicting carotid intima-media thickness in patients with CCCI. Results The levels of hs-CRP, IL-6, TNF-α and CIMT were (1.42 ± 1.55) mg / L, (122.06 ± 28.42) μg / L and (26.48 ± 3.09) pg / ± 0.28) mm, higher than those in the non-thickened group [(0.98 ± 0.82) mg / L, (106.54 ± 21.69) μg / L, (18.58 ± 3.15) pg / ml and (0.81 ± 0.08) (0.62 ± 0.54) mg / L, (78.66 ± 15.87) μg / L, (12.96 ± 2.85) pg / ml and (0.61 ± 0.15) mm] 6, TNF-α levels and CIMT were significantly higher than those in the control group, the differences were statistically significant (P <0.05). Pearson correlation analysis showed that serum hs-CRP, IL-6 and TNF-α levels were positively correlated with CIMT in patients with CCCI (P <0.05). The area under the ROC curve was 0.764. Serum hs-CRP, IL-6 and TNF-α levels could predict the carotid intimal thickening in CCCI patients to a certain extent. Conclusion The combined detection of serum hs-CRP, IL-6 and TNF-α levels can be used to predict CIMT thickening in patients with CCCI.