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目的探讨注射用吡柔比星与胰岛素在葡萄糖注射液中的配伍稳定性。方法分别设置吡柔比星混合葡萄糖注射液、胰岛素混合葡萄糖注射液、吡柔比星与胰岛素混合葡萄糖注射液,观察3组溶液在溶媒浓度5%、10%时变化情况。结果当配伍溶液为5%葡萄糖时,3组配伍溶液24 h内注射用吡柔比星、胰岛素含量差异均无统计学意义(均P>0.05);当配伍溶液为10%葡萄糖时,3组配伍溶液24 h内注射用吡柔比星、胰岛素含量变化明显,差异均有统计学意义(均P<0.05)。结论吡柔比星、胰岛素溶媒为5%葡萄糖注射液时配伍溶液稳定性强;溶媒为10%时稳定性不理想,但药效较好,特殊患者可尝试小剂量应用。
Objective To investigate the compatibility of pirarubicin and insulin in glucose injection. Methods Pirarubicin mixed glucose injection, insulin mixed glucose injection, pirarubicin and insulin mixed dextrose injection were respectively used to observe the changes of the three groups of solutions at 5% and 10% of the vehicle concentration. Results When the compatibility solution was 5% glucose, there was no significant difference in the contents of pirarubicin and insulin between the three groups in 24 h (all P> 0.05). When the compatibility solution was 10% glucose, the three groups Compatibility solution of pirarubicin for injection within 24 h, insulin content was significantly different, the difference was statistically significant (P <0.05). Conclusion The stability of the compatibility solution of pirarubicin and insulin solution with 5% glucose injection is strong. When the solvent is 10%, the stability is not ideal, but the efficacy is better, and the special patients can try low dose.