肿瘤的发生发展与癌基因的活化及抑癌基因的失活密切相关早已得到公认.近年来,多种抑癌基因陆续被发现并明确其作用机制.2007年Rivera等在研究Wilms’瘤时发现了一个新的抑癌基因WTX(Wilms tumor gene on the X chromosome),该基因是第一次在X染色体上发现的直接作为肿瘤抑制因子的基因,并首次在《Science》上报道. In recent years, a variety of tumor suppressor genes have been found and clarified its mechanism of action. In 2007, Rivera et al found that in the study of Wilms’ tumor found that tumorigenesis and development and oncogene activation and tumor suppressor gene inactivation has been recognized A new tumor suppressor gene WTX (Wilms tumor gene on the X chromosome), the first gene found on the X chromosome directly as a tumor suppressor, was first reported in Science.