论文部分内容阅读
目的 探讨氟桂嗪是否有治疗Tourette综合征(多发性抽动秽语综合征)的作用。方法 163例患儿分为3组:泰必利组和泰必利加氟桂嗪治疗组以及单用氟桂嗪治疗组,用药和观察时间至少为6个月,用“不自主运动量表(AIMS)”评分法来评定治疗后抽动症状的改善程度。结果 66例泰必利组中有24例抽动症状消失,痊愈率为36.36％;66例泰必利加氟桂嗪治疗组中有36例抽动症状消失,痊愈率为54.55％,两者痊愈率相比差异有显著性意义(P<0.05)。31例单用氟桂嗪治疗组中“轻度”患儿的痊愈率达100％,即病情偏轻者效果较佳,病情严重者效果较差。结论 氟桂嗪对Tourette综合征确有治疗作用,其药理机制可能与氟桂嗪的抗多巴胺能活性作用有关。
Objective To investigate the effect of flunarizine on the treatment of Tourette syndrome (multiple Tourette’s syndrome). Methods One hundred and sixty-three children were divided into three groups: tiapride group, tiapride plus flunarizine treatment group and flunarizine treatment group. The medication and observation time were at least 6 months. The patients were evaluated with “involuntary movement scale (AIMS) ) ”Score method to assess the improvement of tic symptoms after treatment. Results Totally 66 cases of tixapride group, 24 cases of tic symptoms disappeared, the cure rate was 36.36%; 66 cases of tiapride plus flunarizine treatment group, 36 cases of tic symptoms disappeared, the cure rate was 54.55%, the recovery rate of both The difference was significant (P <0.05). In 31 cases of flunarizine alone, the cure rate of “mild” children was 100%, that is, those with mild disease were better and those with severe disease were less effective. Conclusion Flunarizine does have a therapeutic effect on Tourette’s syndrome, and its pharmacological mechanism may be related to anti-dopaminergic activity of flunarizine.