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本文综述了线粒体分型抗体的某些研究进展,包括分型抗原抗体的某些理化特性、测定方法以及临床意义。线粒体抗体分M1～M9共9个亚型,其中M2、M4、M6、M8、M9型与肝脏疾病有关。M2,M4、M8、M9可见于原发性胆汁性肝硬化(PBC),研究最多的是M2亚型。多数作者认为M2可作为PBC的一种特异性诊断指标,但相反的实验结果也很多。M4除见于PBC外,还可见于慢性胆汁淤积型肝炎和慢活肝。M6与异烟肼引起的药物性肝病有关。
This review summarizes some advances in mitochondrial antibody typing, including some physicochemical properties, assay methods, and clinical implications of typing antigenic antibodies. There are 9 subtypes of M1 ~ M9 mitochondrial antibodies, among which M2, M4, M6, M8 and M9 are related to liver diseases. M2, M4, M8, M9 can be found in primary biliary cirrhosis (PBC), the most studied is the M2 subtype. Most authors believe that M2 can be used as a specific diagnostic indicator of PBC, but the opposite is also a lot of experimental results. M4 except seen in PBC, but also found in chronic cholestatic hepatitis and slow living liver. M6 and isoniazid-induced drug-induced liver disease.