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EB病毒是一种人类疱疹病毒,其原发感染多无临床症状或导致传染性单核细胞增多症。原发感染后,EB病毒终身潜伏于健康人体的B淋巴细胞。但是,部分感染者发展为慢性活动性EB病毒感染,或者出现一些EB病毒相关的恶性疾病,如Burkitt’s淋巴瘤、鼻咽癌、霍奇金淋巴瘤、牛痘样水疱病样淋巴细胞增生性疾病、NK/T细胞淋巴瘤、皮下脂膜炎样T细胞淋巴瘤、血管免疫母细胞T细胞淋巴瘤。本文将详述EB病毒感染的特点、机制,并讨论EB病毒相关皮肤疾病的临床、病理特征。
The Epstein-Barr virus is a human herpes virus, with no clinical signs of primary infection or infectious mononucleosis. After the primary infection, Epstein-Barr virus lurk all the way to healthy human B lymphocytes. However, some people living with HIV develop chronic active Epstein-Barr virus (EBV) infection or develop some Epstein-Barr virus-related malignancies such as Burkitt’s lymphoma, nasopharyngeal carcinoma, Hodgkin’s lymphoma, vaccinia-like blister-like lymphoproliferative disease, NK / T cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma, angioimmunoblastic T cell lymphoma. This article will detail the characteristics and mechanisms of Epstein-Barr virus infection and discuss the clinical and pathological features of EB-associated skin diseases.