1例86岁妇女患者,患食管炎病史10 年,间歇用西咪替丁或雷尼替丁治疗。1989年因症状加重,而始用奥美拉唑(om—eprazole)40mg/d,当时,患者的血清肌酐水平正常。2个月后,出现肾衰而入院;最高血清肌酐为858μmol/L(正常<120)。肾针吸活检示内有浆细胞,淋巴细胞及嗜曙红细胞浸润的间质性炎症和呈斑状分布的肾小管炎症,但不影响肾小球,是急性间质性肾炎的典型特征。入院前2周,患者因疑有肺炎而曾用红霉素治疗。入院后两药均被撤除,经利尿药 A 86-year-old woman with a 10-year history of esophagitis was treated intermittently with cimetidine or ranitidine. Due to the worsening of symptoms in 1989, om-eprazole 40 mg / d was used, and the patient’s serum creatinine level was normal. Two months later, she developed renal failure and was hospitalized; the highest serum creatinine was 858 μmol / L (normal <120). Renal needle aspiration biopsy showed plasma cells, interstitial inflammatory infiltration of lymphocytes and eosinophils and tubulointerstitial inflammation, but did not affect the glomeruli, is a typical feature of acute interstitial nephritis. 2 weeks before admission, the patient had erythromycin for suspected pneumonia. Two drugs were removed after admission, the diuretic