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目的 探讨血管通透性因子 (vascularpermeabilityfactor,VPF)在鼻息肉组织中的表达及意义。方法 将 9例鼻息肉标本及 8例下鼻甲粘膜标本行VPF及其受体flk 1的免疫组化染色 ,光镜观查。结果 VPF在鼻息肉组织的血管内皮细胞和腺体细胞的表达明显高于下鼻甲组织 (P <0 .0 1,P <0 .0 5 ) ,flk 1在血管内皮细胞的表达明显高于下鼻甲组织 (P <0 .0 1)。结论 VPF对鼻息肉发生过程中组织极度水肿的产生可能有非常重要的作用
Objective To investigate the expression of vascular permeability factor (VPF) in nasal polyps and its significance. Methods 9 cases of nasal polyps specimens and 8 cases of inferior turbinate mucosa specimens were subjected to immunohistochemical staining of VPF and its receptor flk 1 by light microscopy. Results The expression of VPF in vascular endothelial cells and glandular cells in nasal polyp was significantly higher than that in inferior turbinate tissues (P <0.01, P <0.05), and the expression of flk 1 in vascular endothelial cells was significantly higher than that in inferior turbinate tissues Turbinate tissue (P <0.01). Conclusions VPF may play a very important role in the occurrence of extreme edema in nasal polyps