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目的观察顺铂(PDD)联合羟基喜树碱(HCPT)组成的PH方案治疗晚期食管癌的近期疗效及不良反应。方法应用PDD(25mg/m~2d1～d3)加HCPT(6mg/m~2d1～d3)治疗晚期食管31例。结果CR2例,NC15例,PD2例,总有效率45.2%;中位TTP2.5月。主要毒副反应为白细胞减少、恶心、呕吐、腹泻,其中Ⅲ～Ⅳ度白细胞减少29.0%,Ⅱ～Ⅲ度恶心呕吐54.8%,Ⅱ～Ⅲ度腹泻12.9%。结论PDD联合HCPT治疗晚期食管癌有较好的疗效,且毒性可以耐受,值得进一步研究。
Objective To observe the short-term efficacy and side effects of PH regimen composed of cisplatin (PDD) combined with hydroxycamptothecin (HCPT) in the treatment of advanced esophageal cancer. Methods PDD (25mg / m ~ 2d1 ~ d3) and HCPT (6mg / m2 ~ 2d1 ~ d3) were used to treat 31 patients with advanced esophagus. Results CR2 cases, NC15 cases, PD2 cases, the total efficiency of 45.2%; the median TTP2.5 months. The main side effects were leucopenia, nausea, vomiting and diarrhea. The grade Ⅲ ~ Ⅳ leukopenia was 29.0%, the grade Ⅱ ~ Ⅲ degree was 54.8%, the grade Ⅱ ~ Ⅲ degree was 12.9%. Conclusion PDD combined with HCPT in the treatment of advanced esophageal cancer has a good curative effect, and the toxicity can be tolerated, worthy of further study.