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过渡金属催化的导向基团辅助的C—H键官能团化反应是当前有机化学的研究热点之一.近年来,利用可离去和/或可修饰导向基团进行C—H键官能团化反应正受到化学家的特别关注并且发展迅速.借助可离去或可修饰导向基团,不但能够大大扩展可利用的碳氢底物,而且对于快速构建分子多样性具有重要作用.作者按不同杂原子(氮、氧、硫、硅等)导向基团进行分类,全面综述了近年来关于可离去和/或可修饰导向基团辅助的各种C—H键官能团化反应的研究进展及合成应用.最后,对该领域所存在的问题和局限性进行了总结,并对今后的发展方向作了展望.
Transition-metal-catalyzed director-assisted C-H bond functionalization is one of the hot topics in current organic chemistry.In recent years, the use of a removable and / or modifiable targeting group for the C-H bond functionalization reaction is Special attention by chemists and the rapid development can be removed or can be modified by the guide group, not only can greatly expand the available hydrocarbon substrate, but also for the rapid construction of molecular diversity has an important role.According to different heteroatoms ( Nitrogen, oxygen, sulfur, silicon and so on), and reviewed the research progress and synthesis applications of various C-H bond functional groups in recent years on the aid of the removable and / or modifiable guide groups. Finally, the problems and limitations in this area are summarized, and the future development direction is forecasted.