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急性呼吸性碱中毒降低脑血流量,增加血红蛋白与氧的亲和力并导致脑缺氧。患者有眩晕感,脑电图呈现迟缓,并可随着供给高压氧而逆转。过度的空气通气可使脑组织和脑脊液乳酸盐增加。后者可随高压氧通气而减低。其他代谢研究表明,过度通气可以减少大脑的能量代谢。本文用狗进行实验,研究了急性呼吸性碱中毒对脑血流和脑供氧的作用,以及吸入氧浓度增加对狗的影响。7条杂种狗用戊巴比妥麻醉后给予恒定容量通气。通过开颅术将涂有聚四氯乙稀的不锈钢导管安放到顶叶,穿进放射冠(Corona radiata),
Acute respiratory alkalosis reduces cerebral blood flow, increases the affinity of hemoglobin for oxygen and leads to cerebral hypoxia. Patients have dizziness, electroencephalogram retardation and reversal of hyperbaric oxygen supply. Excessive air ventilation increases brain tissue and cerebrospinal fluid lactate. The latter can be reduced with hyperbaric oxygen ventilation. Other metabolic studies have shown that hyperventilation can reduce brain energy metabolism. In this paper, dogs were used to study the effect of acute respiratory alkalosis on cerebral blood flow and cerebral oxygen supply, and the effect of inhaled oxygen concentration on dogs. Seven hybrid dogs were anesthetized with pentobarbital given constant volume ventilation. A polytetrachloroethylene-coated stainless steel catheter was placed on the parietal lobe by craniotomy and inserted into Corona radiata.