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在吸取诸家应用防疟药经验的基础上,依据笔者在科纳克里进行的实际调查,经过认真的综合分析,提出如下久居非洲恶性疟高发区服用防疟药的初步方案。选择疗效确切的预防药物或复方制剂3～4种,按一定时间交替使用;在开始的4～6个月内服药间期不宜过长;在容易发病的若干阶段强化预防用药;在离开疫区前后投以适当防治药物。基本方案:居住时间在6个月左右者:仅服乙胺嘧啶(每片6.25mg),每周1次,每次4片。或仅服复方乙胺嘧啶(每片含乙胺嘧啶17.5mg,周效磺胺250mg),每10天1次,每次2片。居住时间在1年左右者:服药方法见表1.表中的复方哌喹每片含磷酸哌喹基质150mg,周效磺胺50mg,盐酸环氯胍
Based on the experience of various anti-malarial drugs, based on the author’s actual investigation in Conakry, after a careful and comprehensive analysis, we propose the following preliminary plan for taking anti-malaria drugs in areas with high incidence of falcipous malaria in Africa. Select the exact effect of the preventive drugs or three to four kinds of compound preparations, according to a certain period of time alternating use; within the first 4 to 6 months medication interval should not be too long; easy to disease in several stages of intensive preventive medicine; Before and after the vote to appropriate prevention and treatment of drugs. Basic program: living in about 6 months: only pyrimethamine (6.25mg per tablet), once a week, each 4. Or only for the compound pyrimethamine (pyrimethamine tablets each containing 17.5mg, sulfasalazine 250mg), once every 10 days, each 2 tablets. Living in about 1 year: the method of taking medicine in Table 1. Table of the compound piperacillin each containing phosphate piperacillin matrix 150mg, sulfasalazine 50mg, cycloguanidine hydrochloride