近十余年来对未成熟儿的管理虽有很大进步,但妊娠不足28～30周婴儿的围产期病死率仍高。在不具备未成熟儿加强监护设备的地方仍愿设法抑制早产。当前主要疗法是静脉输注β-拟交感神经制剂,但由于疗效不理想及难忍的副作用促使寻求更好的药物。体外试验发现子宫肌肉活动受细胞外钙的影响,因此期待钙拮抗剂能抑制子宫收缩。本研究选择妊娠20～35周、单胎、未破膜及子宫收缩至少10分钟一次的孕妇60人,平均分为三组:钙拮抗剂(心痛定)组、β-拟交感神经药(羟苄羟麻黄碱,ritodrine)组和不给药的对照组。为减少其它因素的影响,使三组配对比较更合理,应排除下列情况:多胎、羊水过多、已破膜、宫颈手术史、中三月流产史、早 Nearly ten years of immature children’s management despite great progress, but less than 28-30 weeks of pregnancy infants perinatal mortality is still high. Wherever immature infants do not have the facility to monitor their care, they are still trying to curb premature birth. The current primary therapy is intravenous β-sympathomimetic preparations, but the search for better drugs is prompted by suboptimal and unpleasant side-effects. In vitro tests found that uterine muscle activity by the extracellular calcium, so looking forward to calcium antagonists can inhibit uterine contractions. In the present study, 60 pregnant women, with singleton, unruptured membranes and uterine contraction for at least 10 minutes, were randomly divided into three groups: calcium antagonist (xintongding) group, β-sympathomimetic drug Benzhydroxephedrine, ritodrine) group and a control group not administered. In order to reduce the impact of other factors, the three pairs of paired more reasonable, should exclude the following conditions: multiple births, polyhydramnios, rupture of membranes, history of cervical surgery, history of miscarriage in March