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目的观察葛根素联合复方丹参注射液治疗脑梗死患者的临床效果。方法选取脑梗死患者106例,随机分为对照组和观察组各53例,并选择健康体检的人群53例作为正常组。对照组患者给予降颅压、营养脑细胞、脱水、抗感染、控制血压等西医基础疗法;观察组患者在对照组治疗的基础上给予葛根素联合复方丹参注射液治疗,1周为1个疗程,治疗两个疗程。用神经功能缺损程度评分量表(NIHSS)分别对两组患者入院时、治疗1周、治疗2周的神经功能缺损程度进行评分;测量两组患者入院时、治疗1周、治疗2周血清中白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-9(MMP-9)及超敏C反应蛋白(hs-CRP)的水平,将其与正常组患者的血清因子水平进行对比,并观察两组患者治疗后因子水平的变化情况,比较两组治疗的有效率。结果与入院时比较,两组患者经治疗后神经功能均有所改善,治疗后的NIHSS评分均较治疗前有所降低,以治疗第2周时降低幅度最大,且两组治疗后同时间段相比,以观察组的降低程度尤为明显,差异有统计学意义(P<0.05);脑梗死患者的各项血清炎症因子水平较正常组患者水平有明显上升,差异有统计学意义(P<0.05);两组患者治疗后的各项血清炎症因子IL-6、TNF-α、MMP-9及hs-CRP水平均有所下降,以观察组的下降程度尤为明显,差异有统计学意义(P<0.05);观察组有效率为90.5%,对照组有效率为71.6%(P<0.05)。结论葛根素联合复方丹参注射液能有效改善脑梗死患者的神经功能,降低患者各项血清炎症因子水平。揭示血清炎症因子水平与脑梗死患者的病情严重程度及预后密切相关,药物治疗的重要机制可能在于抑制炎症反应,凸显出中药制剂的优势与特色,值得临床推广应用。
Objective To observe the clinical effect of puerarin combined with compound Danshen injection in patients with cerebral infarction. Methods 106 patients with cerebral infarction were randomly divided into control group and observation group of 53 cases, and 53 healthy subjects were selected as normal group. Patients in the control group were treated with puerarin combined with compound Danshen injection on the basis of the control group. One week was a course of treatment. The patients in the control group were treated with intracranial pressure, nutrient brain cells, dehydration, anti-infection, blood pressure control and other western medicine. , Treatment of two courses. Neurological deficit score scale (NIHSS) were used to evaluate the degree of neurological deficit in the two groups when they were admitted to the hospital for 1 week and 2 weeks respectively. When two groups of patients were admitted to hospital for 1 week and 2 weeks of treatment, (IL-6), tumor necrosis factor-α (TNF-α), matrix metalloproteinase-9 (MMP-9) and high sensitivity C-reactive protein (hs-CRP) The level of serum factor was compared between the two groups, and the changes of the levels of the two groups of patients after treatment were compared. The treatment efficiency was compared between the two groups. Results Compared with admission, the neurological function of both groups improved after treatment. The NIHSS score after treatment was lower than that before treatment, and the greatest decrease was seen at the second week of treatment, and the same period after treatment (P <0.05). The levels of serum inflammatory cytokines in patients with cerebral infarction were significantly higher than those in the normal group (P <0.05), and the difference was statistically significant (P < 0.05). The levels of serum inflammatory cytokines IL-6, TNF-α, MMP-9 and hs-CRP decreased after treatment in both groups, especially in the observation group, the difference was statistically significant ( P <0.05). The effective rate was 90.5% in the observation group and 71.6% in the control group (P <0.05). Conclusion Puerarin combined with Salvia miltiorrhiza injection can effectively improve the neurological function of patients with cerebral infarction and reduce the serum levels of inflammatory cytokines. It is revealed that the level of serum inflammatory cytokines is closely related to the severity and prognosis of patients with cerebral infarction. The important mechanism of drug therapy may be to inhibit the inflammatory response, highlighting the advantages and characteristics of traditional Chinese medicine preparations, which is worthy of clinical application.