论文部分内容阅读
为了评价安徽省麻疹疫苗 (MV)初始强化免疫活动的效果 ,于 1997、1998、1999年在所辖 17个地区开展了流行病学调查、麻疹血清学监测和费用 -效益分析等 ,对MV初始强化免疫活动进行了评价。安徽省麻疹年平均报告发病率在强化免疫前为 7 94/10万 ,对 1～ 6岁儿童开展MV强化免疫后 ,1999年麻疹发病率为 1 36 /10万 ,降低了 82 87% ;1～ 6岁儿童麻疹发病构成 ,强化免疫前为 39 89% ,强化免疫后为 2 5 90 % ,大大减少了 5岁以下儿童的麻疹发病 ;强化免疫后 ,1～ 6岁儿童麻疹IgG抗体阳性率为10 0 % ,抗体几何平均滴度 (GMT)从强化免疫前的 1:16 45增长到强化免疫后的 1:44 92 ,抗体≥ 4倍以上增长率为 36 33%。开展MV强化免疫费用 -效益比值为 1:3 36～ 1:4 70。开展MV初始化强化免疫是加速麻疹控制最有效的措施之一。
In order to evaluate the effect of initial immunization campaigns against measles vaccine (MV) in Anhui Province, epidemiological surveys, measles serological surveillance and cost-benefit analysis were carried out in 17 jurisdictions in 1997, 1998 and 1999, Intensive immunization activities were evaluated. The annual average reported incidence of measles in Anhui Province was 7 94/10 million before intensive immunization. The incidence of measles in 1999 was 1 36/10 million, a decrease of 82 87% after 1 to 6 years of age. The incidence of measles in children aged 6 years was 39 89% before intensive immunization and 25 90% after intensive immunization, which greatly reduced the incidence of measles in children under 5 years of age. The positive rate of measles IgG antibodies in children aged 1 to 6 years after intensive immunization The geometric mean antibody titer (GMT) increased from 1:16 45 before boost to 1:44 92 after boost, and the growth rate of antibodies ≥ 4 fold was 36 33%. The cost - benefit ratio of MV enhancement immunization is 1: 36 ~ 1: 4 70. Carrying out MV initialization is one of the most effective measures to speed up measles control.