压宁定(即乌拉地尔,Ｕｒａｐｉｄｉｌ)为苯哌嗪取代的脲嘧啶衍生物,是一种新型的α1受体阻滞剂。近来研究表明本药治疗高血压急症、慢性阻塞性肺疾患(ＣＯＰＤ)合并肺动脉高压、充血性心力衰竭等效果良好,且副作用相对较小。本文就有关国内外文献综述如下。1　药理作用11　压宁 Press Ning Ding (Urapidil, Urapidil) for the piperazine-substituted uracil derivatives, is a new type of α1 blockers. Recent studies have shown that the drug for the treatment of acute hypertension, chronic obstructive pulmonary disease (COPD) with pulmonary hypertension, congestive heart failure and other good results, and the side effects are relatively small. This article on the domestic and international literature review is as follows. 1 pharmacological effects 11 pressure rather