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目的观察在接受预混胰岛素30R治疗控制不佳的2型糖尿病患者中,联合格列美脲后胰岛素剂量和血糖水平的变化情况。方法开放、自身对照的观察性研究。入选42例原先接受预混胰岛素30R控制不佳的2型糖尿病患者,联合格列美脲治疗12周。结果治疗3个月所有患者全天7点血糖值均较基线下降,平均血红蛋白由9.6%下降至7.3%,42例患者中仅有1例低血糖发生,低血糖发生率为2.4%,节约预混胰岛素剂量33%。结论格列美脲联合预混胰岛素30R治疗2型糖尿病安全、有效、节约预混胰岛素剂量、低血糖发生率低。
Objective To observe the change of insulin dose and blood glucose level in patients with type 2 diabetes who are under the control of premixed insulin 30R. Methodological, observational studies of self-control. Forty-two patients with type 2 diabetes who had undergone poorly controlled pre-mixed insulin 30R were enrolled in combination with glimepiride for 12 weeks. Results All patients at 3 months of treatment had a lower blood glucose level at 7:00 a.m. from baseline, with mean hemoglobin decreased from 9.6% to 7.3%. Only 1 of 42 patients had hypoglycemia, and the incidence of hypoglycemia was 2.4% Mixed insulin dose of 33%. Conclusion The combination of glimepiride and premixed insulin 30R for type 2 diabetes is safe and effective, saving the dose of premixed insulin and low incidence of hypoglycemia.