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机体可以感受氧浓度变化并对缺氧做出适应性反应,基因表达调控是这种适应性反应的一种主要方式。肿瘤细胞对缺氧微环境的适应在肿瘤的进展中起着至关重要的作用。近年来在肿瘤缺氧生物学行为方面的研究取得很大进展。缺氧诱导因子-1(hypoxia inducible factor-1,HIF-1)是缺氧条
The body can feel the changes in oxygen concentration and adaptive response to hypoxia, gene expression regulation is a major way of this adaptive response. The adaptation of tumor cells to hypoxic microenvironment plays a crucial role in tumor progression. In recent years, great progress has been made in the research of biological behavior of tumor hypoxia. Hypoxia inducible factor-1 (HIF-1) is anoxia