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本文以30例胃大部切除术后患者及30例正常人为研究对象,采用腔内单根导管微型传感器测定食管下端括约肌压力(LESP),内镜、病理活检观察食管下端粘膜变化,放免方法测量空腹血清胃泌素浓度。结果:胃大部切除术组与正常对照组食管下端括约肌压力,血清胃泌素浓度分别为15.4±3.3mmHg,22.6±4.5mmHg;44.9±14.9pg/ml,68.4±20.3pg/ml,P<0.01。胃镜及病理检查发现胃大部切除术组有6例有反流性食管炎改变,与临床表现相符.本研究提示:胃大部切除术后LESP降低,并发反流性食管炎,应引起重视。
In this paper, 30 cases of subtotal gastrectomy patients and 30 normal subjects were studied, the intraluminal single catheter miniature sensor was used to detect the lower esophageal sphincter pressure (LESP), endoscopic and pathological biopsy to observe the changes of esophageal mucosa, radioimmunoassay method Fasting serum gastrin concentration. Results: The lower esophageal sphincter pressure and serum gastrin concentrations in subtotal gastrectomy group and normal control group were 15.4 ± 3.3mmHg, 22.6 ± 4.5mmHg, 44.9 ± 14.9pg / ml and 68.4 ± 20.3pg / ml respectively, P < 0.01. Gastroscopy and pathological examination found that 6 cases of subtotal gastrectomy group had reflux esophagitis changes, consistent with clinical manifestations.This study suggests that: LESP reduced after subtotal gastrectomy, concurrent reflux esophagitis, should pay attention to .