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1.锑胺羧螯合物是一种新型的抗肿瘤药物,应用 Sb-26(EDTA-SbNa)、Sb-57(PDTA-SbNa)、Sb-66(HEDT-Sb)和 Sb-71(ATA-Sb)分别为15—20、30—50、25—30和20—40毫克/公斤剂量时,均能显著地抑制小白鼠 Ehrlich 腹水瘤的生长,平均延长生存时间4—22天,延长率36—147%.上述剂量对大白鼠 Guerin 氏癌也有抑制作用,抑制率为58—70%.后3个药物,还能使小白鼠梭形细胞肉瘤腹水型的生存时间延长5—16天,延长率50—160%,其中以 Sb-71的疗效最著.Sb-26、Sb-57、Sb-71、Sb-66对肉瘤180和 AK 肉瘤及前3者对 Ehrlich 固体瘤和淋巴白血病固体型的实验结果,除 Sb-71对肉瘤180有抑制作用外,其他均无疗效.2.4 类锑化合物:3个(月弟)酸化合物(Sb-8,Sb-11和 Sb-42)及1个酒石酸锑(Sb-15),与螯合的间苯二酚锑(Sb-64)和8羟基喹啉锑(Sb-85)各1个,对 Ehrlich 腹水瘤的实验结果,均无明显疗效.3.小白鼠的急性半数致死量,Sb-57和 Sb-71分别为131和62毫克/公斤,亚急性半数致死量分别为75和58毫克/公斤.
Antimony amine carboxylate chelate is a new type of anti-tumor drug. The antimony compound is a new anticancer drug, -Sb) at doses of 15-20, 30-50, 25-30 and 20-40 mg / kg, respectively, significantly inhibited the growth of mouse Ehrlich ascites tumor with an average prolongation of survival of 4-22 days 36-147% .The above dose of Guerin’s cancer in rats also have an inhibitory effect, the inhibition rate of 58-70% .The latter three drugs, but also the mouse spindle cell sarcoma ascites survival time extended 5-16 days, The effect of Sb-26, Sb-57, Sb-71, Sb-66 on sarcoma 180 and AK sarcoma and the first three on Ehrlich solid tumor and lymphoid leukemia solid Type 2 antimony compounds: 3 (cousins) acid compounds (Sb-8, Sb-11 and Sb-42) and 1 One antimony trioxide (Sb-15), one antimony sebacate (Sb-64) and one antimony 8-hydroxyquinoline antimony (Sb-85) each have no significant effect on the experimental results of Ehrlich ascites tumor .3. The acute lethal dose of mice, Sb-57 and Sb-71, were 131 and 62, respectively G / kg, sub-acute median lethal dose were 75 and 58 mg / kg.