论文部分内容阅读
目的 探讨术期未输血对Ｔ细胞亚群的影响；方法 应用Ｔ细胞单克隆抗体ＯＫＴ系列检测了４２ 例口腔癌患者及２０ 例口腔颌面部良性肿瘤患者。其中检测了２２ 例术期未输血和２０ 例术期输血的口腔癌患者的Ｔ细胞亚群。结果 癌瘤患者的ＣＤ３ 、ＣＤ４／ＣＤ８ 值比健康人、口腔良性肿瘤患者明显降低、而ＣＤ８ 值却明显升高；术后ＣＤ８ 值降低，ＣＤ４／ＣＤ８ 值升高。对４２ 例口腔癌患者术后的Ｔ细胞亚群进行了动态观测，术期未输血患者及术期输血患者在术后第３ 、７ 天，ＣＤ３ 、ＣＤ４ 值下降，ＣＤ８ 值降低；术后第１４ 天，未输血组患者ＣＤ３ 、ＣＤ４ 、及ＣＤ８ 值，ＣＤ４／ＣＤ８ 值恢复至术前水平；输血组患者ＣＤ３ 、ＣＤ４ 、ＣＤ８及ＣＤ４／ＣＤ８ 值未恢复至术前水平；术后第２１ 天，未输血组ＣＤ４／ＣＤ８ 值恢复正常而输血组未恢复正常。结论 输血可影响患者免疫功能的恢复进程。
Objective To investigate the influence of non-blood transfusion on T cell subsets during operation. Methods Twenty-two patients with oral cancer and 20 patients with oral maxillofacial benign tumor were detected by OKT series of T cell monoclonal antibody. T cell subsets of 22 patients with oral cancer who had no blood transfusion and 20 blood transfusions were examined. Results The value of CD3 and CD4 / CD8 in cancer patients was significantly lower than that in healthy people and patients with oral benign tumor, while the value of CD8 was significantly increased. The value of CD8 decreased and the value of CD4 / CD8 increased after operation. T lymphocyte subsets in 42 patients with oral cancer were observed dynamically. The patients with no blood transfusion and the patients with transfusion during the operation were observed on the 3rd and 7th day after surgery. The CD3 and CD4 values decreased and the CD8 decreased. At 14 days, the levels of CD3, CD4 and CD8 in patients without blood transfusion and the CD4 / CD8 values returned to their preoperative levels. The levels of CD3, CD4, CD8 and CD4 / CD8 in blood transfusion group did not recover to preoperative levels; , CD4 / CD8 values of non-blood transfusion group returned to normal while blood transfusion group did not return to normal. Conclusion Transfusion can affect the recovery of immune function in patients.