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目的 探讨术期未输血对T细胞亚群的影响;方法 应用T细胞单克隆抗体OKT系列检测了42 例口腔癌患者及20 例口腔颌面部良性肿瘤患者。其中检测了22 例术期未输血和20 例术期输血的口腔癌患者的T细胞亚群。结果 癌瘤患者的CD3 、CD4/CD8 值比健康人、口腔良性肿瘤患者明显降低、而CD8 值却明显升高;术后CD8 值降低,CD4/CD8 值升高。对42 例口腔癌患者术后的T细胞亚群进行了动态观测,术期未输血患者及术期输血患者在术后第3 、7 天,CD3 、CD4 值下降,CD8 值降低;术后第14 天,未输血组患者CD3 、CD4 、及CD8 值,CD4/CD8 值恢复至术前水平;输血组患者CD3 、CD4 、CD8及CD4/CD8 值未恢复至术前水平;术后第21 天,未输血组CD4/CD8 值恢复正常而输血组未恢复正常。结论 输血可影响患者免疫功能的恢复进程。
Objective To investigate the influence of non-blood transfusion on T cell subsets during operation. Methods Twenty-two patients with oral cancer and 20 patients with oral maxillofacial benign tumor were detected by OKT series of T cell monoclonal antibody. T cell subsets of 22 patients with oral cancer who had no blood transfusion and 20 blood transfusions were examined. Results The value of CD3 and CD4 / CD8 in cancer patients was significantly lower than that in healthy people and patients with oral benign tumor, while the value of CD8 was significantly increased. The value of CD8 decreased and the value of CD4 / CD8 increased after operation. T lymphocyte subsets in 42 patients with oral cancer were observed dynamically. The patients with no blood transfusion and the patients with transfusion during the operation were observed on the 3rd and 7th day after surgery. The CD3 and CD4 values decreased and the CD8 decreased. At 14 days, the levels of CD3, CD4 and CD8 in patients without blood transfusion and the CD4 / CD8 values returned to their preoperative levels. The levels of CD3, CD4, CD8 and CD4 / CD8 in blood transfusion group did not recover to preoperative levels; , CD4 / CD8 values of non-blood transfusion group returned to normal while blood transfusion group did not return to normal. Conclusion Transfusion can affect the recovery of immune function in patients.