通过甲酸基犬尿素通路降解形成的色氨酸代谢产物,如羟基邻苯甲酸和喹啉酸,在体外对调节糖代谢的酶有特殊的抑制作用。1953年Kotake等曾报导有关糖尿病患者的色氨酸代谢异常(尿排泄羟基犬尿素和黄尿烯酸增加),而孕妇和接受糖皮质激素或口服 Tryptophan metabolites, such as hydroxy-ortho-benzoic acid and quinolinic acid, formed by the formate-based canine pathway, have particular inhibitory effects on enzymes that regulate glucose metabolism in vitro. In 1953 Kotake et al reported on the abnormal metabolism of tryptophan in diabetic patients (urinary excretion of hydroxytyrosine and uronital increase), while pregnant women and receiving glucocorticoids or oral