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将日本大耳白兔２７只随机分为３组，观察中药通脉降脂口服液在实验性动脉粥样硬化形成中降低血脂、减轻脂质过氧化损伤、调节前列腺素代谢及减轻粥样斑块形成作用。结果表明：通脉降脂口服液可明显地降低实验动物血清胆固醇（ＴＣ）、甘油三酯（ＴＧ）、血浆脂质过氧化物（ＬＰＯ）及血栓素Ｂ_２（ＴＸＢ_２）的含量，升高全血谷胱甘肽过氧化物酶（ＧＳＨ－ｐＸ）活性，调节血栓素Ｂ_２／６－酮－前列环素（６－ｋｅｔｏ－ＰＧＦ_（ｌａ））的平衡，并可使主动脉粥样硬化斑块面积及厚度明显小于胆固醇组。通脉降脂口服液的上述作用可能是其抗动脉粥样硬化作用的主要机制。
Twenty-seven large Japanese white rabbits were randomly divided into three groups to observe that traditional Chinese medicine Tongmai Jiangzhi oral liquid reduced blood lipids, reduced lipid peroxidation injury, regulate prostaglandin metabolism, and reduced atheroma in the formation of experimental atherosclerosis. Block formation. The results showed that Tongmai Jiangzhi Oral Liquid can significantly reduce the levels of serum cholesterol (TC), triglyceride (TG), plasma lipid peroxide (LPO) and thromboxane B_2 (TXB_2) in experimental animals. Blood glutathione peroxidase (GSH-pX) activity modulates the balance of thromboxane B 2 /6-keto-prostaglandin (6-keto-PGF_(la)) and allows aortic atherosclerosis Block area and thickness are significantly smaller than the cholesterol group. The above-mentioned effects of Tongmai Jiangzhi Oral Liquid may be the main mechanism of its anti-atherogenic effect.