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观察硒和维生素A(VA)对支原体肺炎的治疗效果.方法 采用双盲随机对照2×2析因实验设计,选择100例住院支原体肺炎患儿,分为补硒组26例,补VA组23例,补硒和VA组30例以及病例对照组21例,正常组21例.一次补硒量为1mg亚硒酸钠和/或15万单位VA,对照病例组给予常规治疗.结果 与对照组比,治疗后3个补充组的症状和体征缓解天数均有不同程度缩短(P<0.05),补硒组白细胞硒和谷胱甘肽过氧化物酶水平显著上升(P<0.05),补VA、补硒组血清VA水平上升(P<0.01),细胞免疫功能有所改善.结论 硒和VA有协同作用,补充硒或同时加VA,作为辅助治疗支原体肺炎的方法,安全、有效.
To observe the therapeutic effect of selenium and vitamin A on mycoplasma pneumonia.Methods A double-blind randomized controlled 2 × 2 factorial design was used to select 100 cases of children with mycoplasmal pneumonia, divided into selenium-supplemented group (n = 26) and VA-supplemented group Cases, 30 cases of selenium and VA group and 21 cases of case control group, 21 cases of normal group.A selenium dosage of 1mg sodium selenite and / or 150,000 units of VA, the control group given conventional treatment.Results Compared with the control group (P <0.05). The leukocyte selenium and glutathione peroxidase levels in selenium group increased significantly (P <0.05), and VA (P <0.01), and the cellular immune function was improved.Conclusion Selenium and VA have a synergistic effect, selenium or VA plus at the same time, which is safe and effective as a adjuvant therapy for mycoplasmal pneumonia.