单核苷酸多态性指基因组内特定核苷酸位置上存在两种不同的碱基 ,且最少一种在群体的频率不小于1%。由于其丰富、稳定、易实现分析的自动化 ,大规模的 SNP鉴定和公共 SNP数据库的建立已经开始。它作为一种全新的研究工具 ,希望利用它对复杂疾病基因进行大规模的连锁不平衡与相关分析 ,从而促进多基因疾病发病机理的研究和药物基因组学的发展 Single nucleotide polymorphism refers to the presence of two different bases at specific nucleotide positions within the genome, with at least one frequency in the population of not less than 1%. Due to its rich, stable, easy-to-implement analysis automation, large-scale SNP identification and establishment of a public SNP database have begun. As a new research tool, it hopes to use it to carry out large-scale linkage disequilibrium and correlation analysis of complex disease genes to promote the research of pathogenesis of polygenic diseases and the development of pharmacogenomics