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目的探讨人血白蛋白致过敏性休克的临床特点,供临床安全用药参考。方法通过国内有关医药数据库检索人血白蛋白致过敏性休克的病例报告,收集完整病例报告的文献资料,统计分析各病例特征及其用药资料。结果检索得到人血白蛋白引起过敏性休克病例共25例,其中男16例,女9例,年龄范围为6 d~84岁。各病例特征分析显示,人血白蛋白致过敏性休克病例男性和41岁以上中老年患者占比较高,且以速发型过敏性休克为主,循环系统、神经系统和呼吸系统的临床表现较多见,临床症状以血压剧降、寒战、胸闷、紫绀和高热等多见。7例因抢救无效死亡,占比达28%。结论人血白蛋白引起的过敏性休克可造成严重后果,临床须高度重视。
Objective To investigate the clinical characteristics of human serum albumin-induced anaphylactic shock for reference to clinical safety medication. Methods Through the domestic medical database retrieval of human albumin-induced allergic shock case reports, the collection of complete case reports of the literature, statistical analysis of the characteristics of each case and its medication information. Results A total of 25 cases of anaphylactic shock caused by human albumin were retrieved, including 16 males and 9 females, with an age range of 6 d to 84 years. The analysis of the characteristics of each case showed that the proportion of male patients with allergic shock caused by human serum albumin and middle-aged and elderly patients over 41 years accounted for a relatively high proportion, and the majority of the cases were characterized by rapid onset anaphylactic shock. The clinical manifestations of the circulatory system, nervous system and respiratory system were more See, clinical symptoms of rapid decline in blood pressure, chills, chest tightness, cyanosis and fever more common. 7 cases died of rescue ineffective, accounting for up to 28%. Conclusion Anaphylactic shock caused by human serum albumin can cause serious consequences and should be given high priority in clinical practice.