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目的建立用碳糊美托洛尔电极测定美托洛尔片含量的方法。方法利用该电极对美托洛尔的响应,测定美托洛尔片的含量。结果电极的Nernst响应范围为0.01～5.0×10-6 mol.L-1,级差为30.2 mV.pC-1,检出限为3.2×10-6 mol.L-1。结论碳糊美托洛尔电极法可简便、快速、准确地检测片剂中美托洛尔的含量。
Objective To establish a method for the determination of metoprolol tablets by using metoprolol carbon paste. Methods The response of metoprolol to the electrode was measured to determine the content of metoprolol tablets. Results The Nernst response range of the electrode was 0.01-5.0 × 10-6 mol·L-1 with the difference of 30.2 mV.pC-1 and the detection limit was 3.2 × 10-6 mol·L-1. Conclusion Metoprolol carbon paste electrode method can be easily, quickly and accurately detect the tablet metoprolol content.