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介绍６５例尿毒症（ＣＲＦ）患者的急剧恶化因素，对治疗转归等进行了观察。恶化因素以感染占首位（５５．３８％），高血压（舒张压＞１６．５ｋＰａ）占第２位（１５．３８％），心血管及水、电解质紊乱占第３位（各占９．２３％），其次为药物的肾损害及大量高蛋白摄入（各占３．０８％），脑血管意外、恶性肿瘤、输血后（各占１．５４％）。２６例接受了血液透析（ＨＤ），透析率４０％。３９例为非透析（ＵＤ）治疗。总有效率４３％，病死率２９．２％，ＨＤ组好转率占６９．２％，ＵＤ组好转率占２６％，２组有极显著差异（Ｐ＜０．００５）。结合文献讨论了恶化因素及评价治疗效果。
65 cases of uremia (CRF) patients with deteriorating factors, the treatment outcome were observed. Among the worsening factors, infection was the highest (55.38%), hypertension (diastolic blood pressure> 16.5kPa) was the second place (15.38%), and cardiovascular and water and electrolyte disorders were the third (9%). 23%), followed by renal damage and high protein intake (3.08% each), cerebrovascular accident, malignant tumor and blood transfusion (1.54% each). Twenty-six patients underwent hemodialysis (HD) with a 40% dialysis rate. 39 cases of non-dialysis (UD) treatment. The total effective rate was 43% and the mortality rate was 29.2%. The rate of improvement in HD group was 69.2% and the rate of improvement in UD group was 26%. There was a significant difference between the two groups (P <0.005). Combined with the literature discussed the deterioration of factors and evaluation of treatment.