本文报道稀土粉尘经气管内注入两年后,犬Ⅱ型肺泡上皮细胞的酶组织化学改变。与糖代谢有关的酶(HGK、LDH、MDH、ICD)和与呼吸链有关的酶(NADH、CCO)活性下降,导致能量产生不足,从而引起线粒体肿胀和内质网扩张等相应的形态改变。G-6-PD活性下降,影响脂质合成,导致板层体减少。AKP和ANAE活性升高,是大量胞溶酶体形成的结果。 This article reports the rare earth dust after intratracheal instillation two years later, the canine type Ⅱ alveolar epithelial cells enzymatic histochemical changes. Decreased activity of enzymes related to glucose metabolism (HGK, LDH, MDH, ICD) and respiratory chain-related enzymes (NADH, CCO) leads to insufficient energy production, leading to morphological changes such as mitochondrial swelling and endoplasmic reticulum dilation. G-6-PD activity decreased, affecting lipid synthesis, resulting in reduced lamellar body. AKP and ANAE activity, is the result of a large number of lysosomal formation.