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目的:探讨电针百会、水沟治疗急性脑梗死的作用机制.方法:健康SD大鼠40只,雌雄不限,体质量180 ~240 g,随机分为正常组、假手术组、模型组、电针组,每组10只.按改良线栓法制作大鼠大脑中动脉栓塞模型.电针组大鼠造模成功后开始针刺,取穴为“百会”“水沟”.“百会”向前沿皮刺0.5 ~1.0 cm,“水沟”自穴位处向鼻中隔方向斜刺0.2 ~0.3 cm.至针下出现沉紧感时,接G6805-Ⅱ型电针治疗仪,连续波,频率100次/分钟,强度1 mA,通电治疗30 min.酶联免疫吸附法测定血浆D-二聚体含量,凝固法测定血浆纤维蛋白原(Fib)含量.结果:与正常组及假手术组比较,急性脑梗死大鼠血浆D-二聚体、Fib含量均显著升高(P 0.01) ;与模型组比较,电针组大鼠血浆D-二聚体、Fib含量明显降低(P 0.01).结论:电针能显著降低急性脑梗死大鼠血浆D-二聚体、Fib含量,降低血液黏稠度,改善脑部血液循环.“,”Objective To investigate the mechanisms of electroacupuncture(EA) at “Bǎihuì”(百会GV 20) and “Shuǐgōu”(水沟GV 26) for treating cerebral infarction.Methods Forty healthy SD rats were randomly divided into model group(n=10),EA group(n=10),normal group(n=10),and sham operation group(n=10).The model of acute cerebral infarction was established by blocking the middle cerebral artery with an intraluminal thread.EA was applied at “Bǎihuì”(百会GV 20) and “Shuǐgōu”(水沟GV 26) in the rats of EA group after the models were developed.The contents of D-dimer(D-D) and fibrinogen(Fib) were measured in each group.Results The contents of D-D and Fib increased significantly in model group as compared with normal and sham operation groups,respectively(P0.01),and they decreased significantly in EA group as compared with model group(P0.01).Conclusion EA can ob-viously decrease the contents of D-D and Fib,improve abnormal fibrinolysis,lower blood viscosity and ameliorate cerebral blood circulation in the rats with acute cerebral infarction.