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氯氮平治疗对目前通用的精神药物不能耐受的难治性精神分裂症有效,且极少引起锥体外系副作用及迟发性运动障碍。但据报道,该药除能引起1%～2%的粒细胞缺乏症外,还能引起较其它抗精神药物较高的癫痫发作,且与服药剂量有关,当服药量为600～900mg/日时,癫痫发病率为5%;服药量300～599mg/日时,发病率为3%～4%;服药量低于300mg/日时,发病率为1%～2%。本文报道了4例服用氯氮平治疗量或低于治疗量引起癫痫发作的病例,并介绍解
Clozapine is effective in the treatment of refractory schizophrenia, which is currently unaffordable with psychotropic drugs, and rarely causes extrapyramidal side effects and tardive dyskinesias. However, it has been reported that in addition to causing 1% to 2% of agranulocytosis, the drug can also cause seizures that are higher than other antipsychotics and is related to the dosage of 600 mg / day to 900 mg / day , The incidence of epilepsy was 5%; the dosage was 300-599mg / day, the incidence was 3% ~ 4%; when the dosage was less than 300mg / day, the incidence was 1% -2%. This article reports 4 cases of taking clozapine treatment or less than the treatment of cases of seizures caused, and introduced the solution