许多手性药物对映体在体内的药理活性、代谢动力学过程及毒性方面存在显著差异,对其进行分离、分析是一系列体内研究的基础,在手性药物研究中起着重要作用。近几十年来手性化合物的分离分析技术得到了迅速发展,主要为间接法和直接法:间接法是在分离前先与高纯度光学试剂反应形成非对 Many chiral drug enantiomers have significant differences in pharmacological activity, metabolic kinetics and toxicity in vivo, and their separation and analysis are the basis of a series of in vivo studies and play an important role in the study of chiral drugs. In recent decades, the separation and analysis of chiral compounds has been rapidly developed, mainly indirect and direct methods: the indirect method is to react with high purity optical reagents before separation to form non-