论文部分内容阅读
目的 :了解肾病综合征 (NS)和慢性肾功能衰竭 (CRF)患儿的胰岛素样生长因子 Ⅰ (IGF Ⅰ )及其结合蛋白 (IGFBPs)改变的机制。方法 :采用免疫放射法和放射免疫法测定了 2 4例特发性NS (活动期和恢复期各 1 2例 )及 6例CRF患儿的血清IGF Ⅰ和IGF BPs。结果 :NS组活动期及CRF组透析前的血清IGF Ⅰ均显著低于对照组 (P <0 0 1 ) ,而IGFBP 2均显著高于对照组 (P <0 0 1 )。与对照组相比 ,NS组活动期IGFBP 3显著降低(P <0 0 1 ) ,而CRF组血液透析前IGFBP 3显著升高 (P <0 0 5) ;NS组活动期IGFBP 1显著高于对照组 (P <0 0 1 ) ,而CRF组血液透析前的改变无统计学差异。NS恢复期的IGF Ⅰ、IGFBPs与活动期相比 ,差异显著 (P <0 0 1 )。结论 :NS、CRF患儿的IGF Ⅰ的降低 ,但IGFBPs的改变各不相同 ,提示IGF Ⅰ的降低是导致生长障碍的共有因素 ;IGF BPs的改变的不同 ,不仅与肾功能和营养因素有关 ,而且与肾脏疾病有关。
Objective: To investigate the mechanism of insulin-like growth factor Ⅰ (IGF Ⅰ) and its binding protein (IGFBPs) in children with nephrotic syndrome (NS) and chronic renal failure (CRF). Methods: Serum IGF Ⅰ and IGFBPs were measured in 24 children with idiopathic NS (active and convalescent in 12 cases) and 6 children with CRF by immunoradiometry and radioimmunoassay. Results: Serum IGF Ⅰ in NS group and CRF group before dialysis were significantly lower than those in control group (P <0.01), but IGFBP 2 was significantly higher than that in control group (P <0.01). Compared with the control group, the activity of IGFBP3 in NS group was significantly lower (P <0.01), while that in CRF group was significantly higher (P <0.05) before hemodialysis; IGFBP 1 in NS group was significantly higher than that in control group Control group (P <0.01), while there was no significant difference in CRF before hemodialysis. NS recovery IGF Ⅰ, IGFBPs compared with the active phase, the difference was significant (P <0.01). CONCLUSIONS: The reduction of IGF Ⅰ in NS and CRF children, but the changes of IGFBPs are different, suggesting that the decrease of IGF Ⅰ is the common factor leading to growth retardation. The changes of IGFBPs are not only related to renal function and nutritional factors, And related to kidney disease.