Nickel-based superalloy lattice sandwich structures present higher stiffness, higher strength and higher temperature resistance in comparison with other metals. In this study, the Kagome unit was adopted to design the lattice sandwich structure and ProCAST software was used to simulate the filling and solidification processes of the nickel-based superalloy. Grain morphology and sizes of the nickel-based superalloy lattice sandwich structures were simulated by using of cellular automaton coupled with finite element model (CAFE), and indirect additive manufacture combining with investment casting were carried out to fabricate the nickel-based superalloy lattice sandwich structures. The calculated grain morphology and sizes are in good agreement with the experimental results. The grains are mainly equiaxed with an average size of about 500 μm. The simulated results also show that the superheat of melting and the mold preheated temperature have significant influence on the grain size of the Kagome lattice sandwich structures, lower superheat of melting and mold preheated temperatures are encouraged to obtain the fine grains while assuring the integrity of the Kagome lattice sandwich structures for industrial application.