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目的:考察黄芩苷固体分散体片剂的制备与溶出度测定。方法:采用研磨法将辅料和黄芩苷混匀制成分散体,直接压片法制备黄芩苷分散片,利用高效液相色谱(HPLC)测定其溶出度。结果:黄芩苷质量浓度在10～100μ/mL的范围内,质量浓度与峰面积响应值呈良好线性关系,平均回收率100.60%,RSD=1.96%;溶出度测定结果显示120min时溶出均大于75%。结论:该法制备工艺简单,易于操作,溶出度准确可靠。
Objective: To investigate the preparation and dissolution of baicalin solid dispersion tablets. Method: Baicalin was prepared by mixing the excipients and baicalin by grinding method. The baicalin dispersible tablets were prepared by direct compression method. The dissolution rate was determined by high performance liquid chromatography (HPLC). Results: The concentration of baicalin was in the range of 10 ~ 100μ / mL. The linear relationship between mass concentration and peak area was obtained. The average recovery was 100.60%, RSD = 1.96%. The results of dissolution showed that the dissolution of baicalin was greater than 75 %. Conclusion: The method has the advantages of simple preparation process, easy operation and accurate and reliable dissolution.