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目的:观察新清开灵注射液对胶原酶诱导大鼠脑出血后脑组织超氧化物歧化酶(SOD)及脑含水量的影响,探讨其治疗作用的机制。方法:采用胶原酶诱导大鼠脑出血模型,术后尾静脉注射新清开灵注射液,48 h后干湿重法检测脑含水量,黄嘌呤氧化酶法检测脑组织SOD活性。结果:新清开灵注射液能明显降低大鼠脑出血后脑含水量,显著升高脑组织SOD含量。结论:新清开灵注射液能抑制脑出血后氧自由基反应,减轻脑出血后脑水肿。
OBJECTIVE: To observe the effect of Xinqing Kailing injection on brain superoxide dismutase (SOD) and brain water content after cerebral hemorrhage induced by collagenase in rats, and to explore the mechanism of its therapeutic effect. METHODS: The model of cerebral hemorrhage induced by collagenase was used. New Qingkailing injection was injected through the tail vein. The brain water content was measured by dry-wet weight method after 48 h, and SOD activity was measured by xanthine oxidase method. Results: New Qingkailing injection can significantly reduce the brain water content after intracerebral hemorrhage in rats, and significantly increase SOD content in brain tissue. Conclusion: New Qingkailing injection can inhibit the oxygen free radical reaction after cerebral hemorrhage and reduce cerebral edema after cerebral hemorrhage.