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支气管上皮细胞长期受烟雾中的氧化剂等有害物质损伤时,可产生气道及其周围组织的慢性炎症,导致气道结构改变,表现之一为细胞外基质(ECM)结构重塑。基质金属蛋白酶的表达失衡,与ECM代谢紊乱密切相关。近年来发
When bronchial epithelial cells are damaged by harmful substances such as oxidants in the smoke for a long time, bronchial epithelial cells can cause chronic inflammation of the airways and their surrounding tissues, leading to changes in the airway structure. One of the manifestations is the remodeling of extracellular matrix (ECM) structures. The expression of matrix metalloproteinases is unbalanced, which is closely related to the metabolic disorder of ECM. In recent years sent