50名 HBsAg 阳性母亲的婴儿,用国产乙肝疫苗免疫接种,采用0、1、6三剂方案,每剂20μg/ml,肌肉注射。接种乙肝疫苗后1、3、6及12个月时,抗-HBs 阳性率分别为20%、44%、72%与82%;S/N 均值分别为4.98、20.85、60.79与86.72。6月龄时,16名 HBeAg 阴性母亲的婴儿,HBsAg 全部阴性;34名 HBeAg 阳性母亲的婴儿,6名 HBsAg 阳性,占17.6%(6/34),可降低婴儿 HBsAg携带率76.5%。根据血清学检测,婴儿对乙肝疫苗免疫反应有6种类型。 Fifty HBsAg positive mothers of infants were immunized with domestic hepatitis B vaccine and were injected intramuscularly with 0, 1, and 3 doses of 20 μg / ml each. The positive rates of anti-HBs at 1, 3, 6 and 12 months after inoculation were 20%, 44%, 72% and 82%, respectively. The mean S / N were 4.98, 20.85, 60.79 and 86.76.6 Of the 16 HBeAg-negative mothers, all HBsAg-negative infants were negative. Sixteen HBeAg-positive mothers were infants with positive HBsAg (17.6%, 6/34), which reduced the HBsAg carrier rate by 76.5%. According to serological tests, there are 6 types of immune responses to hepatitis B in infants.