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mn 6A甲基化可以调节机体RNA的代谢，参与乳腺癌的发病过程。mn 6A甲基转移酶、mn 6A去甲基化酶、mn 6A结合蛋白共同调节mn 6A甲基化修饰的动态可逆过程。近年来研究显示甲基转移酶样蛋白(METTL)3、MELLT14、KIAA1429、去甲基化酶脂肪和肥胖相关蛋白、YTH结构域家族蛋白1～3等相关因子在乳腺癌中异常表达，可能通过调节mn 6A甲基化和去甲基化过程影响乳腺癌的发生与发展，对其进行深入研究将为乳腺癌的临床诊治提供一个新的思路和靶点。n “,”mn 6A methylation can regulate RNA metabolism and participates in the pathogenesis of breast cancer. mn 6A methyltransferase, demethylase and methylated binding protein regulate the dynamic and reversible process of mn 6A methylation modification together. In recent years, studies have shown that methyltransferase-like (METTL)3, MELLT14, KIAA1429, fat-mass and obesity associated protein, YTH domain family member 1-3 and other related factors are abnormally expressed in breast cancer, which may affect the occurrence and development of breast cancer by regulating the methylation and demethylation process of mn 6A. Further studies will provide a new idea and target for clinical diagnosis and treatment of breast cancer.n