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奥美拉唑为H~+-K~+-ATP酶抑制剂,有很强的抑制基础胃酸和五肽胃泌素等所致的胃酸分泌的作用。本品为一弱碱(pKa=4)。由于遇酸后会迅速转变为不活性型,因此制成肠溶颗粒给药,可由小肠完整吸收,用于治疗Zollinger-Ellison综合征、胃和十二脂肠溃疡,疗效好。 ZollingerEllison综合征 7例病人中6例服大剂量甲氰咪胍无效,口服本品每日1次或2次,持续8～19个月。所有病人2周内症状缓解,4周后溃疡愈合。另11例每日平均服本品70mg(20～160mg),其中10例每日服药1次。1～9个月的治疗期间能持续抑制胃酸分泌。未见毒副作用。胃和十二指肠溃疡
Omeprazole H ~ + -K ~ + -ATPase inhibitors, there is a strong inhibition of gastric acid and pentagastrin caused by gastric acid secretion. This product is a weak base (pKa = 4). Because of the case of acid will quickly change to inactive type, so made of enteric granules administered, can be completely absorbed by the small intestine, for the treatment of Zollinger-Ellison syndrome, stomach and duodenal ulcer, curative effect is good. Six of the seven patients with Zollinger-Elison’s Syndrome were ineffective at high doses of cimetidine and were orally administered once or twice a day for 8-19 months. Symptoms were relieved in 2 weeks in all patients and ulcers healed after 4 weeks. The other 11 cases of the average daily dose of this product 70mg (20 ~ 160mg), of which 10 cases a day medication. 1 to 9 months of treatment can continue to inhibit gastric acid secretion. No toxic side effects. Stomach and duodenal ulcer