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病人一般不喜欢服用無色澄明的液体药物,而認为帶色药液才有药效;同时我們药房工作人员在一些毒剧药液中亦常加入一些着色剂,这样可以引起我們調配时的注意,以避免差錯。着色剂种类很多,我們选擇着色剂时也会發生一些問题,如某院药房配制鹽酸可卡因(Cocainae Hydro-chloridum)液,用曙紅鈉(Eosinum Natricum)液作着色剂,結果加入曙紅鈉时,鹽酸可卡因液中产生了沉淀,經研究結果知为中和反应,曙紅鈉之結構中具酚及羧酸鈉鹽,故其水溶液显碱性,而鹽酸可卡因为弱硷与强酸所成之鹽,水溶液显酸性,二者的溶液相遇起中和反应,有一部分游离的可卡因和曙紅析出,使溶液产生沉淀。
Patients generally do not like to take colorless and clear liquid medicines, and think that colored liquid medicines have efficacy. At the same time, our pharmacy staff often add some coloring agents to some poisonous drug liquids, which can cause our attention during deployment. To avoid mistakes. There are many types of colorants, and we also have problems with the choice of colorants. For example, Cocainae Hydro-chloridum hydrochloride is used in a pharmacy and Eosinum Natricum is used as a colorant. As a result, sodium is added. At the time, a precipitate was formed in the hydrochloric acid cocaine solution and the result of the investigation was known as a neutralization reaction. The structure of the sodium erythrosene contained phenol and carboxylic acid sodium salt, so the aqueous solution was alkaline, and the hydrochloric acid cocaine was formed by weak hydrazine and strong acid. The salt, the aqueous solution is acidic, the solution of the two meets the neutralization reaction, and some of the free cocaine and blush are precipitated, which causes the solution to precipitate.