在HIV感染中,几乎所有个体都能产生具有中和能力的各种抗体,中和抗体既可以中和游离的病毒颗粒,发挥抗病毒作用,又可以作用于被病毒感染的细胞,发挥保护性作用进而使感染得到控制[1]。在HIV感染的急性期,体内病毒水平首先被免疫系统所控制,此时中和抗体往往处于缺乏状态,表明在HIV感染急性期,中和抗体在机体抗病毒的免疫控制反应中居于次要地位[2],细胞免疫反应则更为关键,发挥主导作用。然而,在HIV感染的慢性期,中 In HIV infection, almost all individuals can produce a variety of neutralizing antibodies, neutralizing antibodies can both neutralize free virus particles, play an anti-virus effect, but also can be applied to the virus infected cells, play a protective In turn, the infection is controlled [1]. In the acute phase of HIV infection, the virus level in the body is first controlled by the immune system, where neutralizing antibodies are often deficient, indicating that neutralizing antibodies are secondary to the antiviral immune-control response in the acute phase of HIV infection [2], cellular immune response is more critical, play a leading role. However, in the chronic phase of HIV infection,