报道４例肺小细胞癌导致的副肿瘤性边缘叶脑炎，其中单纯型和复合型各２例。全组均有记忆障碍。ＷＡＩＳ测定，智商４８～７７。癫痫３例，抑郁状态及定向障碍２例。合并感觉性神经元病及感觉运动性神经元神经病各１例。免疫组化显示４例患者血清、脑脊液及尿液中存在特异性神经元抗核抗体（Ｈｕ抗体）。结合文献对副肿瘤性边缘叶脑炎的临床分类、病理特点、病因和发病机制进行了讨论。 Report of 4 cases of paraneoplastic marginal leaf encephalitis caused by small cell lung cancer, including simple type and complex type in 2 cases. All groups have memory impairment. WAIS determination, IQ 48 ~ 77. 3 cases of epilepsy, 2 cases of depression and disorientation. 1 case of sensory neuron disease and sensory motor neuron disease. Immunohistochemistry showed that there were specific neuronal antinuclear antibodies (Hu antibodies) in serum, cerebrospinal fluid and urine of 4 patients. The clinical classification, pathological features, etiology and pathogenesis of paraneoplastic marginal leaf encephalitis were discussed in combination with the literature.