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目的观察美托洛尔联合赖诺普利治疗慢性充血性心力衰竭(CHF)的临床疗效。方法96例CHF患者随机分为:对照组(n=46)给予洋地黄及利尿剂等常规治疗,治疗组(n=50)在常规治疗的基础上口服赖诺普利10mg/d,美托洛尔(12.5～100mg/d),疗程均为6个月。结果治疗后治疗组患者心功能改善、血压下降、心率减慢、心胸比缩小,左室舒张末期内径(LVDd)及左房内径(LAd)均明显减小,左室射血分数(LVEF)增加(P<0.05),明显优于对照组;且副作用少、患者耐受性好。结论赖诺普利联合美托洛尔治疗CHF疗效肯定、副作用少,值得临床推广。
Objective To observe the clinical efficacy of metoprolol combined with lisinopril in the treatment of chronic congestive heart failure (CHF). Methods A total of 96 CHF patients were randomly divided into control group (n = 46) and routine therapy such as digitalis and diuretic. The treatment group (n = 50) received lisinopril 10mg / d on the basis of routine treatment, Lol (12.5 ~ 100mg / d), treatment were 6 months. Results After treatment, the patients in the treatment group had improved cardiac function, decreased blood pressure, slowed heart rate, reduced cardiothoracic ratio, left ventricular end-diastolic diameter (LVDd) and left atrial appendage (LAd) and left ventricular ejection fraction (LVEF) (P <0.05), significantly better than the control group; and less side effects, patients with good tolerance. Conclusion The combination therapy of lisinopril and metoprolol has a definite curative effect on CHF, with few side effects and worthy of clinical promotion.