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目的分析中药注射液出现配伍变化的原因及其处理方式。方法回顾性分析我院近年中药注射的临床应用情况,对引发其配伍变化的原因进行分析总结,并探讨临床应对措施。结果产生配体变化的原因为主要为:混合液性状发生改变、配伍后有效成分有影响、pH变化对配伍的影响及出现混合性微粒。结论中药注射液配伍过程中易出现有效成分改变,混合液稳定性下降、热原与不溶性微粒递增等不良反应,需加强临床应用时的监测。
Objective To analyze the reason and treatment of compatibility changes in traditional Chinese medicine injection. Methods Retrospective analysis of clinical application of traditional Chinese medicine in our hospital in recent years, the reasons for the changes that led to its compatibility analysis and discussion of clinical response measures. Results The main reason for the change of ligand was: the change of mixed liquor traits, the influence of active ingredients after compatibility, the effect of pH change on compatibility and the appearance of mixed particulates. Conclusion Traditional Chinese medicine injection compatibility process prone to changes in the active ingredient, the stability of the mixture decreased, pyrogen and insoluble particles increased adverse reactions, the need to strengthen the monitoring of clinical applications.