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目的:观察替咪沙坦与厄贝沙坦对老年高血压患者的降压疗效。方法:86例轻、中度老年高血压患者,随机分为替咪沙坦组(46例)与厄贝沙坦组(40例),分别给予替咪沙坦80 mg/d或厄贝沙坦150 mg/d,晨起顿服。比较治疗前、与治疗后8周血压变化情况,及末次用药后动态血压监测后6 h血压水平。结果:2组治疗后收缩压及舒张压均下降,与治疗前比较差异有统计学意义(P<0.05);替咪沙坦组收缩压和舒张压下降幅度较厄贝沙坦组明显(P<0.05);末次给药后动态血压监测后6 h替咪沙坦组平均收缩压和平均舒张压低于厄贝沙坦组(P<0.05)。结论:替咪沙坦与厄贝沙坦对老年高血压患者均有明显的降压疗效,常规剂量替咪沙坦较厄贝沙坦的降压作用显著、持久。
Objective: To observe the antihypertensive effects of telmisartan and irbesartan on elderly hypertensive patients. Methods: A total of 86 patients with mild and moderate essential hypertension were randomly divided into two groups: the group receiving peglitazone (46 cases) and the group receiving irbesartan (group: 40 cases), giving 80 mg / d or 90 mg / Tanzania 150 mg / d, morning meal Dayton clothing. The changes of blood pressure before treatment, 8 weeks after treatment, and 6 h after ambulatory blood pressure monitoring after last administration were compared. Results: The systolic blood pressure and diastolic blood pressure decreased after treatment in both groups, with statistical significance (P <0.05). The decrease of systolic blood pressure and diastolic blood pressure in the patients with irbesartan was significantly lower than that of the irbesartan group <0.05). Mean systolic blood pressure and mean diastolic blood pressure were lower in irbesartan group than those in irbesartan group at 6 h after the last administration of ambulatory blood pressure (P <0.05). Conclusion: Both mioxartan and irbesartan have significant antihypertensive effects on elderly patients with hypertension. The antihypertensive effect of conventional doses of temsirolimus and irbesartan is significant and lasting.