【摘 要】
：
Dawson-type phosphotungstic polyoxometalate a/β-K6P2W18O62·10H2O(P2W18) was synthesized and its inhibitory effect on the mushroom tyrosinase was investigated.
【机 构】
：
School of Bioengineering,Yanwu Affiliated Hospital of Zhongshan Hospital
论文部分内容阅读
Dawson-type phosphotungstic polyoxometalate a/β-K6P2W18O62·10H2O(P2W18) was synthesized and its inhibitory effect on the mushroom tyrosinase was investigated.It could inhibit diphenolase activity of mushroom tyrosinase as an irreversible inhibitor.When the concentration of the enzyme reached 0.0176 mg/mL,the concentration of P2W18 leading to 50％ activity lost(IC50) was 0.05 mmol/L for monophenolase and 0.64 mmol/L for diphenolase.In addition,the antimicrobial activity of P2W18 was evaluated by zone of inhibition test.The results show that P2W18 possesses effective antimicrobial ability against Escherichia coli,Bacillus subtilis,yeast,especially Escherichia coli and yeast.
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